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WSU IEHS Faculty Profile for Thomas Kocarek
PMID: 15635043 Fang HL, Abdolalipour M, Duanmu Z, Smigelski JR, Weckle A, Kocarek TA, Runge-Morris M. Regulation of glucocorticoid-inducible hydroxysteroid sulfotransferase (SULT2A-40/41) gene transcription in primary cultured rat hepatocytes: role of CCAAT/enhancer-binding protein liver-enriched transcription factors. Drug Metab Dispos. 2005 Jan;33(1):147-56. PMID: 15502011 Shenoy ...
www.iehs.wayne.edu

WSU IEHS Faculty Profile for Susan Xu
Aug;14(4):303-14. PMID: 15353127 Wang G, Xu XS. Peptide nucleic acid (PNA) binding-mediated gene regulation.Cell Res. 2004 Apr;14(2):111-6. PMID: 15115611 Chen Z, Xu XS, Yang J, ... , 44 (3): 238. Wang G and Xu XS. 2002. Peptide Nucleic Acids (PNA) Binding-mediated target gene transcription. “Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics” S.W.Kim and R.I. Mahato ed. Taylor & ...
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MIT finds that engineered yeast improves ethanol production - EnergyPortal.eu
The key to the MIT strategy is manipulating the genes encoding proteins responsible for regulating gene transcription and, in turn, controlling the repertoire of genes expressed in a particular cell. These types of transcription factors bind to DNA and turn genes on or off, essentially controlling what traits a cell expresses. The traditional ...
energyportal.eu

Our Stolen Future: Affecting other hormone systems
National Academy of Sciences USA. 92:6157-6160 Harmon et al. report that methoprene and its metabolic derivatives interact with the mammalian retinoid X receptors and thereby stimulate gene transcription in vertebrates. Methoprene, an insect growth regulator, is used in agriculture and domestic settings as a pesticide because of its ability to prevent insect metamorphosis from larval to adult ...
ourstolenfuture.org

IISG - Aquaculture Projects
Objectives: The long-term goal of this project is to develop a cell-mediated gene transfer approach to the production of transgenic fish. To accomplish this goal, we are working ... of the germ cell marker gene, vasa. Cells expressing vasa were identified by immunohistochemical staining with an antibody that recognizes the vasa protein, by reverse transcription polymerase chain reaction (RT-PCR) ...
www.iisgcp.org

Our Stolen Future: A list of endocrine-disrupting compounds
Styrene dimers and trimers Estrogen Estrogen receptor agonists Ohyama et al. 2001 Metals Compound Hormones affected Mechanism References Arsenic Glucocorticoid Selective inhibition of DNA transcription normally stimulated by the glucocorticoid-GR complex. Kaltreider et al. 2001 Cadmium Estrogenic Activates estrogen receptor through an interaction with the hormone-binding domain of the ...
www.ourstolenfuture.org

Evolution, Mass Extinctions, and Mass Speciations
RNA transcription, and DNA replication). Distinctions are made between the two strands of a DNA duplex and ... as "living fossils" today. This is known as the Lazarus Effect. This shows that shuffling gene sequences can be a major aspect of evolution, and as shown in many experiements, the ...
livingcosmos.com

Gene Therapy Nightmare for Mice
RNA interference underworld is huge, comprising some 97 to 98 percent of the transcription activity in the cell, and the specificity depends on low levels of the correct sequences being ... of life thats the essence of the fluid genome [7] (Living with the Fluid Genome). Gene therapist should really take an appropriately holistic and systems view of genetics and biology before ...
www.i-sis.org.uk

Gene Therapy Woes
SiS 17). The retroviral vector had inserted near the gene LMO2, which encodes a transcription factor, whose over-expression has been implicated in child-hood T-cell ... addition, deletions of host DNA tend to occur at the site of insertion. Immune responses Gene therapy vectors usually contain parts of bacteria, viruses, or other microorganisms. Immune responses can occur ...
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Are Human-chimp Differences Due To Gene Regulation, Not Genes ?
This rapid evolution in transcription factors occurred only in humans." "For 30 years scientists have suspected that gene regulation has played a central role in human ...
primates.com